多杀菌素又名多杀霉素(Spinosad)是在刺糖多胞菌(Saccharopolyspora spinosa)发酵液中提取的一种大环内酯类无公害高效生物杀虫剂。产生多杀菌素的亲本菌株土壤放线菌多刺糖多孢菌（Saccharopolyspora spinosa Metrz & Yao）最初分离自加勒比的一个废弃的酿酒场。
多杀菌素（Spinosad）是由土壤放线菌经有氧发酵产生的胞内次级代谢产物，属于大环内酯类化合物，由于其对靶标害虫特别是鳞翅目害虫高效，对非靶标生物...
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关键词： 丁烯基多杀菌素； 须糖多孢菌； 多杀菌素； 刺糖多孢菌 [gap=1120]Key words: butenyl-spinosyns; saccharopolyspora pogona; spinosyns; saccharopolyspora spinosa
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Spinosad,highly active on a wide variety of insect pests,less-persistent,safe for non-target organisms,having unique insecticide mechanism and no cross-resistance to the existing stored-grain insecticides,was a novel microbial and green stored-grain protectant with high prospects.
多杀菌素广谱高效、低残留、对非靶标动物安全,同时杀虫机理独特,与现有储粮害虫防治药剂不存在交叉抗性,是一种极具应用前景的微生物源绿色储粮防护剂。
参考来源 - 多杀菌素防治储粮害虫的研究进展In this paper, we are aimed to improve the spinosyn-producing strain by genome shuffling, optimization of fermentation process and scale-up of fermentation processes in 2.5 L fermentor.
本论文运用基因组重排技术对多杀菌素产生菌进行选育，并优化了其发酵工艺，最后进行了2.5L发酵罐小试。
参考来源 - 多杀菌素产生菌基因组重排育种研究In addition, the conditions of shaking flasks' fermentation were optimized. The result indicated that the productivity of spinosad on the optimal fermentation condition reached 567.1μg/ml, which was 2.98 times as much as that on the original condition.
实验结果表明，发酵工艺优化后，多杀菌素的效价比未优化时提高了1.98倍，达到了567.1μg／ml。
参考来源 - 多杀菌素产生菌的诱变育种与发酵工艺研究·2,447,543篇论文数据，部分数据来源于NoteExpress
杀虫素：某些放线菌产生的抗生素如阿维菌素，多杀菌素。
D. insecticidal element: some actinomycetes produce antibiotics such as abamectin, sterilization element.
同时，对原生质体再生菌株的形态与多杀菌素产量变化进行了比较研究。
In addition, we compared the change of morphology and spinosyns yield of the regenerated strains.
本论文根据多杀菌素的生物合成途径和代谢调节机理，对刺糖多孢菌进行理性化选育。
A rational selection procedure was developed based on the biosynthetic pathway and metabolic regulation of spinosad.
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