...性痴呆是最常见的神经系统退行性疾病之一，以进行性的认知功能损害、基底前脑胆碱能神经元(basal forebrain cholinergic neurons, BFCNs)退变、神经元纤维缠结和β-淀粉样肽沉积为主要特点。
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本文探讨了脑源性神经营养因子、神经生长因子对体外长期培养的胚基底前脑胆碱能神经元是否具有延缓退变的作用。
The delaying effects of BDNF and NGF on the degeneration of the long term cultured embryonic basal forebrain cholinergic neurons in vitro were studied.
结论雌激素补充治疗能选择性影响基底前脑各亚区NOS和胆碱能神经元，并有可能影响学习和记忆能力。
Conclusion estrogen replacement can selective effect on the different basal forebrains subregion NOS and cholinergic neurons, and may concern ability of learning and memory.
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