...化,并利用生物信息学分析检测结果,从而分离筛选出鸡脂肪细胞分化的负调控转录因子,最后应用基因过表达(Gene overexpression)和RNA干扰技术(RNA interference)对分离筛选的鸡脂肪细胞分化的负调控转录因子进行功能验证。
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基因过度表达 gene overexpression
Objective To investigate the effects of visfatin gene overexpression on blood lipid level in rats.
目的:探讨visfatin基因过表达对大鼠血脂的影响。
参考来源 - visfatin基因过表达对大鼠血脂的影响The experiments of inoculation period and availability of oxygen indicated that the over-expression strains and wild type of Pseudomonas M18 had different requirements in cultural conditions.
而通过接种时间和摇床转速等反应条件的比较试验,结果表明,在野生株和phzD基因过表达菌株之间,发酵生产PCA的条件存在一些差异。
参考来源 - 假单胞菌M18中PCA合成酶的作用比较研究·2,447,543篇论文数据,部分数据来源于NoteExpress
像老年痴呆症这样的疾病会影响NR2B的表达,而可以使该基因过表达的药物能够抵消这些疾病的影响。
Diseases like Alzheimer's affect NR2B expression, so a drug that causes the gene to over-express could counteract the affects of the disease.
这只转基因鼠小弟名叫荷比-杰。通过使控制其神经元传输的基因过表达,它走迷宫和记忆玩具的能力得到了极大的提升。
The genetically engineered rat, Hobbie-J, over-expresses a gene that regulates neuron communication, greatly enhancing the rat's ability to navigate mazes and remember toys.
基因无效或过表达的生理学模型将成为珍贵的检测这些生物新发现的工具。
Physiological models with invalidated or over-expressed genes will be precious tools to check these new biological discoveries.
You're taking a normal gene and you're over expressing it or expressing it more abundantly than normal in one particular spot of the body to have an effect.
我们在讨论一个正常基因的过表达,也就是在体内某一点的表达量,大大超过正常水准从而产生疗效
You do that by expressing the genes in the mice in the way that I described on the last slide and it's shown in a little bit more detail on this slide.
按照我上张幻灯片讲过的方法,在小鼠中表达外源基因,这张幻灯片中对此有更详细的表述
You've heard about RNA interference, for example, and that is the process of stopping this, to stop a gene from being expressed.
比如说,你们听说过的RNA干扰,就是一种阻止,基因表达的手段
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