MGMT和TP53基因在保持基因组稳定性和防止细胞突变或癌变方面具有重要的功能。
MGMT and TP53 genes play an important role in maintaining genomic stability and protecting cells against mutations or carcinogenesis.
以酵母为模式生物，利用表观遗传，分子遗传和生物化学等手段，研究表观遗传调控在维持基因组稳定性中的作用。
Using yeast as model organism, study the contribution of epigenetic regulation to the maintenance of genomic stability, by epigenetic, molecular genetic and biochemic approaches.
在这些基因组稳定性控制发生改变的肿瘤中，化疗诱导的基因改变的累积可能会导致细胞死亡和解释对化疗产生完全反应。
In these tumours with an altered control of genomic stability, accumulation of chemotherapy-induced genetic alterations may contribute to cell death and account for complete response.
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