目的：在人类基因组中，有98%的DNA序列属于非编码序列。
Objectives: 98% of DNA sequence in human genome belongs to non-coding sequence.
研究背景：组织特异的基因表达是由基因组非编码区中的调控模块和对应的蛋白反式因子共同决定的。
BACKGROUNDTissue specific pattern of gene expression is probably determined by regulatory modules encoded in the genome DNA and trans-regulatory apparatus.
比较基因组学的研究发现： 人类基因组中约5%的序列受到选择压力的限制， 但编码序列只占其中很小一部分， 约3.5%是保守、非编码序列。
Study of comparative genomics has revealed that about 5% of the human genome are under purifying selection, 3.5% of which are conserved non-coding elements (CNEs).
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