结论黑色素瘤的发生可能与基因组不稳定性有关。

Conclusion The occurrence of melanoma might be associated with genetic genomic instability.

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有很多原因可以解释，包括：乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。

There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways.

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依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。

Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).

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