补充 基因本体(Gene Ontology,GO)是一个在生物信息学领域中广泛使用的本体。它主要包括三个分支: 生物过程、分子功能和细胞组件。
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The relatedness between the target protein and the auxilary proteins is derived through intuitive biological meaning, based on which to transfer to the target protein the gene ontology knowledge of homologous proteins and statistically correlated proteins.
通过直观生物意义建立目标蛋白和辅助蛋白之间联系,将同源蛋白基因本体知识、基因本体库内统计相关的基因本体知识迁移给目标蛋白,在此基础上构建一个多核学习模型,用于蛋白亚细胞定位预测。
参考来源 - 基于机器学习的蛋白亚细胞定位预测Enrichment analysis in Gene Ontology categories of the differentially expressed gene found that 34 differential expressed proteins were highly associated with Osteonecrosis of the femoral head.
通过基因本体论蛋白功能分析发现,其中34种蛋白质与股骨头缺血性坏死密切相关。
参考来源 - 非创伤性股骨头缺血性坏死的高通量蛋白质组学研究·2,447,543篇论文数据,部分数据来源于NoteExpress
基因本体论集与一些不同的生物体的分子功能,生物过程,和细胞成分的信息。
Gene ontology gathers information for molecular function, biological processes, and cellular components with a number of different organisms.
本文通过分子功能基因本体论比较了不同模式生物基因产物分子功能分布的异同。
The molecular functions were compared between different model organisms based on molecular function Gene Ontology.
MGD与生物信息学社区在生物医学本体论的开发和使用上合作,例如 基因本体论和 哺乳动物表型本体论。
MGD collaborates with the bioinformatics community on the development and use of biomedical ontologies such as the Gene Ontology and the Mammalian Phenotype Ontology.
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