目的研究脆性组氨酸三聚体（FHIT） 基因异常转录与结肠癌的相关性。
Objective To study the relationship between aberrant FHIT transcription and colon carcinoma.
肝癌中存在FHIT基因高甲基化、转录异常、FHIT蛋白表达下降。
There exist hypermethylation, abnormal transcription of FHIT gene and down-regulation expression of FHIT protein in liver cancer.
文中主要综述了几十年来人们对DNA甲基化异常与基因转录及肿瘤发生之间关系的研究进展，尤其是最近的研究突破。
This article reviews the advances of researching relation between DNA methylation aberrance and transcription and tumorigenesis in the last decades, especially a recent breakthrough in cancer.
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