...工程科技Ⅰ_论文宝库 制备 63 2.3 磁性复合微球载药量(Drug loading efficiency,DLE)和药物包封率(Drug entrapment efficiency,DEE)的测定 63 2.4 左氧氟沙星检测方法的建立 63 2.5 载药聚甲基丙烯酸磁性复合微球的..
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...2010年硕士论文 制备 63 2.3 磁性复合微球载药量(Drug loading efficiency,DLE)和药物包封率(Drug entrapment efficiency,DEE)的测定 63 2.4 左氧氟沙星检测方法的建立 63 2.5 载药聚甲基丙烯酸磁性复合微球的..
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和药物的包封率 Drug entrapment efficiency ; DEE
利用扫描电镜和紫外光谱考察了内相聚合物浓度和搅拌速度对微球粒径和药物包封率的影响。
The effects of polymer concentration and agitation rates on the size of microspheres and drug incorporation efficiency were studied by scanning electronic microscopy (SEM) and UV-spectrophotometry.
方法:以包封率和平均粒径为评价指标,采用星点设计-效应面法优化醇质体处方中大豆磷脂、药物和无水乙醇的最佳配比。
METHODS Taking encapsulated ratio and average diameter as evaluation index to optimize the best matching of soybean phospholipid, drug and absolute alcohol in ethosomes.
结果:通过调节药物浓度和不同高分子组合筛选出突释小,包封率高且缓慢释放的处方。
Results: By adjusting LDME concentration and different polymer combinations, we achieved microspheres with high encapsulation efficiency, low initial burst and sustained release.
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