...心 sferase,NAT)可催化乙酰基从乙酰CoA上转移到异烟肼的氮原子上;组蛋白乙酰转移酶(HAT)和组蛋白脱乙酰基酶(histone deacetylase, HDAC)分别催化组蛋白N-端残基上的乙酰化和去乙酰化,而酰基化和去酰基化又是真核生物蛋白质翻译后修饰中最普遍...
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目的：临床试验中对组蛋白脱乙酰基酶阻滞剂(HDACi)的研究目的在于诱导细胞分化，生长停止，和肿瘤细胞的凋亡。
Purpose: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells.
本发明提供了用于抑制组蛋白脱乙酰基酶酶活性的化合物和方法。
The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity.
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