对于结直肠肿瘤发生，已经报道两种形式的基因组不稳定：MSI和染色体不稳定(chromosomal instability，CIN)。林武华等［7］的研究表明错配基因修复突变引起MSI是导致结直肠癌发生的机制之1。
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在2002年，他就得出了一个能预测癌症演化和扩散方式的方程组，比如说染色体何时开始变得不稳定，使得癌细胞在转移中发生变异。
In 2002 he worked out equations that can predict the way cancer evolves and spreads, such as when mutations emerge in a metastasis and chromosomes become unstable.
本文就DNA错配修复、染色体不稳定和肿瘤之间的联系予以综述。
This paper reviewed the relationship between DNA mismatch repair, chromosome instability and cancer.
端粒的长度随着年龄和细胞分裂次数的增加而逐渐变短，因而导致染色体不稳定，因此端粒长度的变化与细胞衰老密切相关。
The length of telomeres gradually decreases with increasing age and cell division number, which can lead to chromosome instability, so the changes in telomere length are closely linked to cell aging.
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