...会论文摘要集》2005年 录调控密切相关,由组蛋白乙酰转移酶(histone acetyltransferases,HATs)和去乙酰化酶(histone deacetylases,HDACs)所催化。组蛋白的高乙酰化通常与基因活化有关,而低乙酰化状态往往与基因活性的抑制相关。
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...m豆丁网 表明，组蛋白 在组蛋白乙酰基转移酶（histone aeetyltransferases；HATs）和去乙酰化酶（histone deacetylases，HDACs）的交替作用下，通过改变染色质的结构参与基因表达的调控。
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和组蛋白去乙酰化酶 Histone Deacetyltranferase ; histone deacetylase
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
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