目的：探讨RASSF1A基因启动子区甲基化与喉癌的关系。
Objective To investigate the relationship between promoter methylation of RASSF1A gene and laryngeal squamous cell carcinoma.
方法：运用甲基化特异性P CR，检测RASSF1A基因在48例喉癌组织、相对应癌旁组织及48例正常人外周血中的启动子区甲基化情况。
Methods a methylation-specific PCR was performed to detect the promoter methylation of RASSF1A gene in 48 tumor tissues, 48 corresponding normal tissues and 48 normal blood plasma.
在启动子区域的DNA甲基化是抑制基因活性的一种重要机制。
DNA methylation in the promoter regions is a powerful mechanism for the suppression of gene activity.
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