哺乳动物细胞只能识别单链RNA,如果细胞的防御机制发现了双链RNA就会破坏它以保护机体不受病毒的感染。
Mammalian cells make only the single-stranded variety. If a cell’s defence mechanisms detect double-stranded RNA they destroy it, to protect against infection.
虽然公司目前的产品都属单一药物性质,但公司持有开发双药物纳米细胞的许可证。
Although its current products are based on single drugs, the company does hold a license to develop dual-drug nanocells.
哺乳动物细胞对双链RNA不识别意味着可用短发卡RNA来阻断信使RNA,从而使相应基因的信号无法传递。
This aversity to double-stranded RNA means short hairpins can be used to knock out the messengers, thus nullifying the signal from the underlying gene.
Certain double stranded RNA sequences will cause in the cell a process of degradation of very specific RNA sequence.
一些双链RNA序列能够在细胞中开启,特定RNA序列的降解程序
The end result is you can design now very specific double stranded RNA sequences, that when delivered into cells again will activate this process of natural degradation of an existing messenger RNA.
最终的结果是,你现在能够设计针对性很强的,双链RNA序列,当这段序列被转入细胞后会激活,对已有信使RNA进行降解的过程
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