...蛋白八聚体紧密结合却为基因的表达设置了障碍，要打 组蛋白去乙酰化酶的组蛋白去乙酰化酶 组蛋白去乙酰化酶(histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰组蛋白去乙酰化酶抑制剂通过控制DNA缠绕于组蛋白的松紧程度来发挥作用。
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组蛋白去乙酰化酶 HDAC ; histone deacetylase ; histone deacetylases HDACs ; hi stone deacetyltransferases
芳乙酰胺去乙酰化酶 AADAC
组织蛋白去乙酰化酶 HD
人组织蛋白去乙酰化酶 Human HD ; Human Histone Deacetylase ELISA KitELISA ; HD ELISA Kit
去乙酰化酶抑制剂 histone deacetylase inhibitor HDACi ; HDACI
白去乙酰化酶 histone deacetylase ; HDAC
芳乙酰铵去乙酰化酶 AADAC
和去乙酰化酶 histone deacetylases ; HDACS
蛋白去乙酰化酶 histone deacetylase ; HDAC
Some therapies have been developed targeting the epigenetic changes in prostate cancer,including DNA methyltransferases and histone deacetylase inhibitors,and have achieved certain desirable results.
目前已有一些针对前列腺癌表观遗传改变的治疗,主要有DNA甲基化转移酶和组蛋白去乙酰化酶抑制剂,并取得了一定的效果。 相信随着对表观遗传学研究的深入,必将为前列腺癌的治疗开辟一条新思路。
参考来源 - 前列腺癌的表观遗传学研究进展·2,447,543篇论文数据，部分数据来源于NoteExpress
认识到开发新颖治疗剂的要求，本发明提供新颖组蛋白去乙酰化酶抑制剂。
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
目的研究组蛋白去乙酰化酶抑制剂MS275对人多发性骨髓瘤细胞U266增殖的影响。
ObjectiveTo investigate the antitumor effect of MS275, a histone deacetylase inhibitor, on growth of the human myeloma cell line U266.
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