小鼠的造血和血管系统起源于胚外中胚层。胚胎期6.5-7天时在卵黄囊形成特征性的血岛结构发生向造血和内皮细胞的分化。
The hematopoietic and vascular systems of the mouse arise from extraembryonic mesoderm that migrate through primitive streak to the presumptive yolk sac between days 6.5 and 7.0 of gestation.
结论：乙醇可能通过抑制器官发生期脏层卵黄囊的发育诱导胚胎畸形的发生。
CONCLUSION: alcohol exposure in vitro can affect the development of mouse VYS, which may contribute to the teratogenic effect of alcohol.
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