目的证实结扎致单侧输尿管梗阻(uuo)大鼠模型梗阻侧肾脏是否存在低氧，不同时间点低氧的特点及低氧与肾间质纤维化的关系。
Purpose To observe whether hypoxia exists in the obstructed kidney of unilateral ureteral obstruction (UUO) rat model and its distribution relationship with tubulointerstitial fibrosis.
目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。
To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction(UUO)rats.
方法采用左侧输尿管结扎的方法建立单侧输尿管梗阻（UUO）雄性CD-1 小鼠动物模型。
Methods The animal model of renal disease was induced by unilateral ureteral obstruction (UUO) in CD-1 mice.
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