即协同刺激信号是免疫活性细胞活化需要的第二双信号刺激，是抗原提呈细胞表面协同刺激分子与淋巴细胞表面协同刺激分子受体结合、相互作用后产生的。
第一信号为抗原与T细胞受体TCR的结合，第二信号为抗原递呈细胞上的协同刺激分子与T、B淋巴细胞上的受体结合。
The first signal is the binding of antigen with TCR on T cells. The second signal is the binding of co-stimulate on the APC with their receptors presenting on T and B lymphocytes.
角膜移植手术失败的主要原因是T细胞介导的免疫排斥反应，T细胞的充分活化需要共刺激信号的协同作用。
The leading cause of corneal graft failure is T cell-mediated immune rejection. Costimula-tion has been shown to be necessary for full activation of naive T cell.
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