用敲除Epac2基因表达小鼠的研究显示Epac2介导GLP-1R激动剂艾塞那肽-4的作用增加第一相葡萄糖-刺激胰岛素分泌(GSIS)动力学组分[54]。因为在用T2DM患者中第一相葡萄糖-刺激胰岛素分泌(GSIS)是有缺陷的[55],和因为在T2DM的条件下艾塞那肽-4恢复第一...
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通过当血糖变得太高时刺激胰岛素分泌以及降低食欲来起作用。
It works by stimulating the release of insulin only when glucose levels become too high and by inhibiting appetite.
它不仅可以刺激胰岛素分泌,还可以抑制胰高血糖素的分泌,正如李教授所说,这一作用非常重要。
It does stimulate insulin secretion but it also suppresses glucagon secretion and that is very important as Professor li just pointed out.
研究者在哥伦比亚大学发现水平增加骨钙素的小鼠都刺激胰岛素分泌细胞的胰腺和增加胰岛素敏感性。
Researchers at Columbia University found that increased levels of osteocalcin in mice both stimulated the insulin-producing cells in the pancreas and increased insulin sensitivity.
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