近年来，肿瘤坏死因子受体超家族成员- OX40 (CD134)，作为一共刺激分子对于维持CD 4 + T细胞的活化、增值、存活起到关键性作用。
In recent years, tumor necrosis factor receptor (TNFR) family member-OX40 (CD134), as a key co-stimulatory molecule, involved in maintenance of activation, proliferation, survival of CD4 + t cells.
第一信号为抗原与T细胞受体TCR的结合，第二信号为抗原递呈细胞上的协同刺激分子与T、B淋巴细胞上的受体结合。
The first signal is the binding of antigen with TCR on T cells. The second signal is the binding of co-stimulate on the APC with their receptors presenting on T and B lymphocytes.
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