...分别74%、66%、40%、10%；Kurashige分析了190例接受拉米夫定长期治疗慢性乙型肝炎患者初始病毒学应答（initial viral responese，IVR）与YMDD变异的相关性。IVR定义为治疗6个月时HBV DNA水平＜104拷贝/ml。
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本研究通过回顾性分析拉米夫定治疗慢性乙型肝炎的疗效与患者基线特征、有无初始病毒学应答（initial virological response，IVR）及不同治疗方案的关系，初步研究拉米夫定疗效的的影响因素，为拉米夫定的优化治疗提供依据。
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有无初始病毒学应答 initial virological response ; IVR
我们也知道有些初始应答较慢的患者，没有获得快速病毒学应答，但可能在12,16或24周时病毒检测阴性，对于这些患者延长治疗可能会有好处。
We know that slower initial responders, those that don't have a rapid viral response, but maybe become negative by week 12, 16, or 24, that extending therapy may also be of some benefit.
结论：IFN在治疗初始就能激活NK细胞，其细胞毒性作用被强烈诱导，这与病毒学应答相关。
CONCLUSIONS: IFN activates NK cells early after treatment is initiated. Their cytotoxic function, in particular, is strongly induced, which correlates to the virologic response.
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