癌基因，肿瘤抑制基因的发现促进了对细胞周期及细胞凋亡机制的深入理解。使人们对肿瘤发生和发展的认识也日趋深入。
The discovery of oncogene and tumor suppressor gene has deepened human beings understanding of the mechanisms of cell cycle and cell apoptosis as well as the mechanisms of tumorigenesis.
目的：比较B，C两种基因型HBV核心蛋白在促进肝细胞凋亡方面的差异，以期初步阐述HBV基因型与临床关系的发病机制。
AIM: To compare the proapoptosis effect of hepatitis B virus (HBV) genotype B and C core proteins on liver cells, and explore the pathogenesis of HBV infection with different genotypes.
本研究发现SPATA4基因能够抑制细胞衰老和细胞凋亡、促进细胞周期的推进与细胞增殖；
This research reveals that SPATA4 gene can inhibit cellular senescence and apoptosis as well as promote the progression of cell cycle and cell proliferation;
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