内源性抗原(endogenous antigen),指在抗原提呈细胞内新合成的抗原,如病毒感染细胞合成的病毒蛋白、肿瘤细胞内合成的肿瘤抗原等。
本文建立了蛋白酶体裂解内源性抗原蛋白的QSAR模型来研究蛋白酶体对抗原蛋白裂解的特异性,并采用PLS方法求解模型。
The QSAR model of proteasomal cleaving antigen protein is built in order to study the specificity of the proteasome cleaving antigen protein, and PLS method is used to solve the model.
本研究还发现,检测石蜡切片肝组织内抗原时,阻断内源性生物素并不是一个必不可少的步骤。
In this study, it also has been shown that blocking endogenous biotin is not a necessary procedure in detecting tissue antigen on paraffin embeded section.
结论:抗原诱导的气道微血管渗漏反应与内源性速激肽有关,CP - 96345对此有选择性抑制作用。
CONCLUSION: Endogeneous tachykinins play a role in the antigen-induced airway microvascular leakage, which can selectively be inhibited by CP-96345.
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