共刺激信号（costimulatory signals）是1970年由 Brestcher和Cohn在T细胞激活双信号学说的基础上首先提出并证实的。
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论文:稳心颗粒治疗功能性室性早搏疗效观察-中大网校论文网 关键词】 共刺激信号；特发性血小板减少性紫癜；自身免疫 [gap=691]Key wordscostimulatory signal; ITP; autoimmunity
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As one pair of the important costimulatory molecules, OX40/OX40L pathway provides the important costimulatory signal to activate T and B cells in the process of immune response.
在机体的免疫应答过程中，OX40／OX40L作为一对重要的共刺激分子，为T、B细胞的激活提供了重要的共刺激信号。
参考来源 - 人OX40L转基因细胞的构建与单克隆抗体的研制及其生物学功能的研究The competitive inhibition rate of anti-CD80-ScFv from murine parent antibody 4E5 was 98.67%,and anti-CD80-ScFv could make the proliferation rate of PBMC decline by 43.48% via blocking costimulation signal mediated by CD80.
抗CD80-ScFv对鼠源亲本抗体4E5与抗原结合的竞争抑制率达98.67%,并能阻断CD80介导的共刺激信号转导,抑制PBMC的增殖,增殖率下降43.48%。
参考来源 - 抗人CD80单链抗体的构建、表达及与抗原结合的特性分析·2,447,543篇论文数据，部分数据来源于NoteExpress
同时，通过处理共刺激信号的方法诱导免疫耐受在异体手移植中具有一定的应用前景。
Meanwhile co-stimulating signal induced immunological tolerance is proved promising for the application of hand transplantation.
角膜移植手术失败的主要原因是T细胞介导的免疫排斥反应，T细胞的充分活化需要共刺激信号的协同作用。
The leading cause of corneal graft failure is T cell-mediated immune rejection. Costimula-tion has been shown to be necessary for full activation of naive T cell.
目的最新实验数据显示了CD 2 8 B7和CD 40 CD 15 4共刺激信号通路在T细胞活化与效应过程中起重要作用。
Objective Recent experimental data indicate that the costimulatory signal pathways of CD28 B7 and CD40 CD154 offer essential roles for t cell activation and effecting.
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