当这些细胞被激活，它们表面会标记一种免疫检查点蛋白，称为PD1，是“关闭”开关的一种，能够关闭免疫应答。
When these cells are called to activeduty, their extracellular armor is marked with an immune checkpoint protein, atype of "off" switch called PD1 that can be used to shut down the immuneresponse.
PD-L1免疫组化可能在肿瘤免疫表型鉴别诊断、精确筛选抗PD-1/PD-L免疫检查点治疗方面有一些作用。
PD-L1 immunohistochemistry may have some role in the immunophenotypic differential diagnosis of tumors and pinpointing potential candidates for anti-PD-1/PD-L immune checkpoint therapy.
本综述根据临床前研究的结果和不断涌现的临床数据，总结目前对于免疫检查点调节剂的认识，并评估其在胶质母细胞瘤治疗方面可能发挥的作用。
This Review summarizes current knowledge on immune checkpoint modulators and evaluates their potential role in glioblastoma on the basis of preclinical studies and emerging clinical data.
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