What's the matter with you
... What's the deadline 截止到什么时候？ What's the matter with you 你怎么啦？ What's the purpose of your visit 你来访的目的是什么？ ...
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... What were you up to 你干什么去了 What's come over you 你怎么啦 What's cooking 发生了什么事 ...
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What is wrong with you? 你怎么啦 Nothing. I am in excellent health.
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短语
你今天是怎么啦
You today is how friends