目前临床上分子靶向治疗主要分为以表皮生长因子受体(EGFR)为靶点的治疗和以肿瘤血管生成(VGFR)为靶点的治疗以及其他基因突变治疗药物(如RAS抑制剂新药安卓健,MEK抑制剂新药司美替尼等等),主要包括表皮生长因子受体酪氨酸...
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血管生成与肿瘤的生长、侵袭和转移密切相关,目前,以抑制血管生成为靶点治疗肿瘤有望成为抗肿瘤新疗法之一。
Angiogenesis is required for invasive tumor growth and metastasis. Inhibition of angiogenesis is considered to be a promising approach of antitumor therapy.
这些直接以NGF为靶点的治疗在引起细胞增殖下降的同时,还可促进 细胞凋亡和抑制肿瘤血管生成。
Such treatments directed against NGF induced a decrease in cell proliferation with a concomitant increase in apoptosis of breast cancer cells and an inhibition of tumor angiogenesis.
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