亚慢性毒性是指实验动物连续多日接触较大剂量的外来化合物所出现的中毒效应。所谓较大剂量,是指小于急性LD50的剂量。
亚慢性毒性试验(subchronic toxicity test)是研究试验动物在多次给以受试物时所引起的毒性作用,试验期通常为动物生命期的1/30~1/10,大鼠一般为3~6个月,狗为4~12个月。
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亚慢性及慢性毒性试验 Subchronic and chronic toxicity
方法包括急性毒性试验、蓄积毒性试验及亚慢性毒性试验。
Methods Toxicology studies included acute toxicity test, accumulated toxicity test and sub chronic toxicity test.
方法采用亚慢性毒性试验方法,大鼠经口灌胃染毒,试验期为6周。
Methods Subchronic toxicity test was applied. The rats were exposed to arsenic by oral perfusion at gradient doses for 6 weeks respectively.
结论本试验提示百年乐对大鼠亚慢性毒性试验及小鼠毒性试验未产生不良影响。
Conclusion No adverse effects of Bainianle dietetic liquid were observed on subchronic toxicity test of rats and toxicity test of mice.
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