低的肾小球滤过率是存在糖尿病肾损害的危险信号，糖尿病肾损害最终会进展为肾衰，即终末期肾损害，此时需要透析治疗或肾脏移植。

A low GFR is a dangerous sign of existing diabetic kidney disease that can progress to kidney failure, also called end-stage kidney disease, which requires dialysis or kidney transplantation.

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它以双肾多发性囊肿为特征，囊肿不断形成和进行性增大，导致肾功能下降，到60岁时大约有50％的患者进展至终末期肾衰。

Progressive cyst formation and enlargement leads to loss of renal function, hypertension, and in 50% of cases, end-stage renal disease by the age of 60 year.

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