fight against the fate ; struggle with fate
... fight 常指个人或象征性的冲突，也可指与逆境的抗争。如： the fight against fate 与命运抗争 consultation n. 请教，咨询，磋商，会诊 ...
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人与命运的抗争 Journal of Yuncheng University
我认为与命运抗争没有什么用。
I see no use arguing with fate.
《柯林斯英汉双解大词典》
那么，那些长大了却还在与命运抗争、找不到人生方向的青年男女们呢？
What about the son or daughter who is grown but seems to be struggling and wandering aimlessly through early adulthood?
youdao
所谓的“与命运抗争”，就是这个意思。
This is just it what is so-called "Struggling against fate".
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