肥胖青少年与正常青少年在血糖\血脂等方面差异的研究(1) (调查研究) 关键词】青少年肥胖；胰岛素抵抗；瘦素抵抗 [gap=1209]Key words】Adolescent obesity;Insulin resistance;Leptin resistance
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...康复 Chinese Journal of Clinical Rehabilitation] 瘦素抵抗、胰岛素抵抗与非酒精性脂肪肝病 [医学综述 Medical Recapitulate] 肿瘤坏死因子α基因多态性与非酒精性脂肪性肝病胰岛素抵抗的相关性 Association between tumor necrosis factor-alpha gene pol...
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结论：人类肥胖的发生可能与瘦素抵抗而不是瘦素缺乏有关。
Conclusion: Obesity in humans may be due to leptin resistance rather than to leptin deficiency.
然而后来的研究发现，肥胖的人并不缺乏足够的瘦素。其原因尚不完全清楚，但他们存在瘦素抵抗。
But later research found that obese people don't lack sufficient leptin. For reasons not fully understood, their cells are resistant to it.
瘦素抵抗、血清高瘦素浓度等病理状态时，瘦素可能影响前脂肪细胞的增殖及进一步分化为脂肪细胞，调节肥胖发生。
Leptin maybe regulate the generation of obesity through acting on the proliferation and differentiation of preadipocyte at the state of leptin resistance and high leptin concentration in serum.
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