印迹调控区域(Imprinting control regions, ICRs)或称差异甲基化区域(Differentially methylated regions, DMRs)的甲基化水平差异是印迹基因体现 其亲源差异表达的重要条件。
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中国生物化学与分子生物学报 /H19基因座上的印记控制区(imprinting control region, ICR)和DNA甲基化区域(DNA methylated regions, DMR)元件等.许多转录因子参与绝缘子的基因调控作用,例如脊椎动物中的CCCTC结合因子(CCCTCbin
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如果这些区域变成甲基化,它往往压制有关的基因转录。
If these areas become methylated, it tends to suppress transcription of the gene in question.
未来可以深入研究某种甲基化差异和具体疾病的关系,然后针对那些区域用药治疗。
Future research could peg where certain methylation differences are associated with specific diseases, then target those areas with drugs or other treatments.
斯维特研究小组最近发现,小鼠的电击空间关联训练降低其海马区DNA甲基化,而海马区是脑部记忆形成的重要区域。
Sweatt's team recently discovered that training mice to associate a certain location with a mild electric shock reduced DNA methylation in the hippocampus, a brain region crucial for memory formation.
In some cases that backbone gets methylated and those regions of the DNA that are methylated get treated differently by the cell than unmethylated regions.
一些情况下,主链会甲基化,该甲基化区域的DNA,和未甲基化区域的DNA,会被细胞区别对待
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