心脏雌激素/孕酮替代研究（heartandestrogen/progestinreplacementstudy，HERS）是一项HRT对妇女冠心病二级预防随机双盲对照的前瞻性研究。
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心脏和雌/孕激素研究 heart and estrogen /progestin replacement study
但是比较研究当中的年轻女性和老年女性的心脏病风险上，雌激素使用还是有着令人惊奇的区别。
But there were surprising differences in the risks and benefits of estrogen use on heart risk when comparing the youngest and oldest women in the study.
每10 000个女性在她们70岁左右的时候，使用雌激素之后，有16个额外心脏病概率，19个意外死亡以及48个重大的不良事件。
For every 10, 000 women in their 70s, using estrogen would cause 16 extra heart attacks, 19 extra deaths and 48 serious adverse events.
研究人员发现在啮齿类动物中有一种被称为27-羟基胆甾醇或27HC的小分子，它可与心脏血管内的雌激素受体结合。
The researchers found that in rodents, a molecule called 27-hydroxycholesterol, or 27HC, binds to the same receptors in the blood vessels of the heart to which estrogen binds.
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