Endogenouscannabinoids (endocannabinoids), which are synthesized from lipidprecursors in plasma membranes, are signaling lipidsconsistingofamidesand esters oflongchainfatty acids.
Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists.