Osteoprotegerin which was discovered by Simonet in 1997 is a decoy receptor of RANKL regulating bone metabolism. Osteoprotegerin can bind to RANKL competing with RANK and block the binding of RANK and RANKL, which result in dysmaturity of osteoclast.
骨保护素(osteoprotegerin,OPG)是1997年由Simonet等6发现出一种能够调节骨代谢的糖蛋白RANKL的诱饵受体,它可以和RANK竞争与RANKL结合,从而阻断RANK与RANKL的结合,导致破骨细胞分化成熟障碍。
参考来源 - 重组人骨保护素对聚乙烯颗粒刺激破骨细胞功能的影响·2,447,543篇论文数据，部分数据来源于NoteExpress
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