The jump wasn't driven by a few high-profile drug problems, such as Merck's withdrawal of painkiller Vioxx in 2004 and Pfizer's suspension of rival painkiller Bextra in 2005.

暴涨不能归因于少数世人瞩目的药物问题，如2004年的默克公司止痛药万络退市和辉瑞公司类似的止痛药Bextra暂停上市。

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He introduced a Chinese version of Good Manufacturing Practice guidelines, which ensure that production is up to standard and that a mechanism is in place to deal with drug problems.

他组织起草了GMP指南的中国版，使得药品生产符合规范，并引入一套机制来处理药品问题。

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She says these sculptures comment on problems in society such as drug use and smoking.

VOA: special.2010.07.09

And you also have classes that will give you an insight into, someone is coming to see you, who has an alcohol problem, a drug abuse problem, things you will engage in daily activities, boyfriend girlfriend problems, having trouble in class.

和其他课程，比如,有一个人来找你咨询，他有酗酒或者是吸毒问题，或者其他会在日常生活中遇到的问题，男友女友的问题，课堂上的问题等等。

普林斯顿公开课 - 人性课程节选

"Over the last few months, there have been a number of training centers open that are exclusively for members of both the Afghan National Army and the Afghan national police force, and I would say that drug usage and illiteracy are two of the big problems within the security forces that NATO has really made a big priority now.

VOA: standard.2010.06.23

Have you noticed more white-collar felons stating that they have drug problems prior to sentencing?

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Ms Lewis said the event could help people who are facing alcohol and drug problems.

BBC: Breakin' Out: Tinchy Stryder and alcohol ban at festival

Even in major urban centers wrestling with drug problems, the patterns are elusive to many public-policy specialists.

FORBES: Narcotics