No challenge anywhere can be allowed to jeopardize the goal of permanently improving the world by driving out a truly awful disease.

任何地方的任何挑战都不得危及我们的目标，这就是消灭一种非常可怕的疾病，使世界得到永久改善。

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The immense challenge of honing the same level of driving skill as a top racing driver is unbelievably addictive and satisfying.

磨炼出和顶级车手一样的驾驶技术是一项极大的挑战，这项挑战有着让人难以置信的沉溺感和满足感。

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Business executives at Acme are faced with the challenge of driving more revenue from an existing customer base.

Acme的业务主管们面对着从现有的客户群中产生更多收入的挑战。

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Now add to this the challenge of driving on the left side of the road, steering wheel to the right, for the first time in your life and oenology becomes more sport than science.

FORBES: Driven to Drink of McLaren Vale

And although some of the reforms Thailand has undertaken are aimed at restoring confidence and stemming the present contraction, it is the continuing development challenge that is driving much of the activity.

ECONOMIST: How much should you bet on Thailand?

And though there can be little comparison between the speed and the danger of the two driving disciplines, Webber insists the challenge presented by karting is one that still excites him.

CNN: Go-kart crazy: Where F1 dreams begin