Desensitization and Downregulation 去敏感性及抑低调节
Dopamine receptor downregulation and hypersensitization 多巴胺接受器的紊乱
N a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces 减量调节
Conclusion Downregulation of CGRP on the expression of P53 protein in ischemic neurons might promote the recovery of the ischemia neurons.
结论CGRP下调缺血神经元p 53蛋白的表达，可能对缺血神经元的恢复有促进作用。
Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of its protein expression and through phosphorylation-dependent degradation (4).
生长因子退出后，通过下调蛋白表达和磷酸化依赖性蛋白降解，周期蛋白D的水平下降（4）。
Downregulation of these pathways in normal organs can lead to vascular disturbances and even regression of blood vessels, which could be intensified by concurrent pathological conditions.
在正常器官中，这些信号途径下调能导致血管紊乱，甚至血管衰退，而且这些都可能由于同时发生的病理状态而加重。
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