...变化对垂体脉冲式释放FSH和LH是极为重要的，它可以从两方面调节FSH、LH分泌，即升调节(up-regulation)和降调节(down-regulation)又称双相反应(diphasicreaction)。
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receptor down-regulation 受体减量调节 ; 受体下行调节 ; 受体向下调节 ; 受体下调
down regulation [生理] 减量调节 ; 向下调节 ; 受体下调
down-regulation of receptors 受体的向下调节 ; 受体的衰减性调节
up or down regulation 上调或下调
Pituitary down-regulation 垂体降调节
receptors down-regulation 受体下调
In conclusion, the down-regulation of FPG cut point for the diagnosis of IFG had its rationality.
综上所述，IFG诊断切点的下调具有合理性。
参考来源 - 糖尿病前期人群的特点及转归研究The down-regulation of HAb18G/CD147 was shown to result in the degradation of E-cadherin and disruption of cell-cell contacts.
下调HAb18G/CD147可以导致E-cadherin在24 hr后逐步降解,细胞间连接断裂。
参考来源 - 哺乳动物工程细胞悬浮适应—可贴壁亚群（HEK293ar）的获得及其抗失巢凋亡机制研究·2,447,543篇论文数据，部分数据来源于NoteExpress
N a decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces 减量调节
Heat shock protein(HSP) shows both biological effects of up-regulation and down-regulation on apoptosis. Especially the suppressive effects on apoptosis provide a new path to treat various diseases.
热休克蛋白（HSP）对细胞凋亡有双向调控作用，尤其是其抗细胞凋亡的作用为临床多种疾病的治疗开辟了新的途径。
Results The obtained results showed that 143 genes revealed up-regulation and 101 genes showed down-regulation.
结果研究发现有143条基因在给药组中发生上调，101条基因发生了下调。
Conclusion: The over-expression of IGF-1R and down-regulation of PTEN expression may play a role in pathologic scar.
结论：IGF - 1r的高表达和PTEN的表达下调在病理性瘢痕形成中起重要作用。
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