The Tar Heels (52-8) take on fourth-seeded Canisius (42-15) on Friday evening after second-seeded Florida Atlantic (39-20) faces third-seeded Towson (29-28) in the opener of the double-elimination regional.
First baseman Mark Teixeira and third baseman Kevin Youkilis are likely to be activated for Friday's series opener against Boston following two-day minor league injury rehabilitation assignments at Double-A Trenton.