Patients had a four-week dose titration period followed by 24 weeks of treatment.

病人有四个星期的剂量滴定期之后，24周的治疗。

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For example, in patients with renal failure or chronic renal disease, we need to be very careful to reduce the dose of the drug by titration.

例如，肾衰或慢性肾病的患者，我们需要非常小心的逐步减少药物剂量。

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First, an inadequate dose may be given, which may require a longer course of hospitalization until titration to the proper dose is achieved.

第一，应考虑到剂量不足，调到合适的剂量需要相当长一段时间。

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