The prothrombotic state associated with metabolic risk should be treated with lifestyle modification measures and in appropriate individuals with low-dose aspirin prophylaxis.

对于即将有血栓形成状况的代谢危险患者应改善其生活习惯，对个别有适应症的患者可给予小剂量阿司匹林进行预防。

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Mechanisms of resistance, such as behavioral change, physiological modification or metabolic detoxification, decrease the effective dose available at the target site.

行为改变、生理学上的变化或代谢解毒等抗性机制能够降低毒物到达靶标的有效剂量。

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