...dose finding, bivariate binary model [gap=134]关键词：优化的实验设计，受到惩罚的实验设计，复合优化设计，约束优化设计，剂量发现，二元二元模型 ...
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dose-finding 剂量探索
We are now in the process of planning a dose finding pivotal trial to optimize the dosing regime and demonstrate the efficacy of the drug.
我们正在规划一个寻找最佳剂量和证明药物的有效性的关键性试验。
Perhaps the most potent finding is that just a single dose of alcohol in the late evening can zap the efficacy of your z's.
也许最有效的发现是，在深夜饮用一剂量的酒精会抵消睡眠的功效。
The paper investigates designs of dose-finding trials, the purpose of which is to determine the maximum tolerated dose (MTD).
本文研究的是药物最大耐受剂量（MTD）的识别方法。
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