So if long-term high dose administration were needed in clinics, function of liver and kidney should be monitored.

如果临床需要大剂量长期使用，应注意肝、肾功能的检查。

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They caution that parents who are giving these supplements to children should be aware of the possible damaging consequences of long-term, high dose administration.

他们警告说，那些给予儿童补充上述物质的父母要小心，长期、高剂量的补充上述物质可能会对儿童造成伤害。

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On scan days, baseline scans were followed by intravenous administration of nicotine at a dose equivalent to the nicotine delivered by 1.5 cigarettes.

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Although it is sold over-the-counter, melatonin isn't approved by the Food and Drug Administration and researchers disagree on the optimal dose.

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Both El-Masri and Milani say the U.S. Food and Drug Administration should keep a close eye on the top dose of Zocor.

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