Defects in DNA damage response can cause genome instability, which induces many human cancers.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
In this way, studying the efficacy of DNA damage response inhibitors on HBV infection and replication was available.
通过这种方式，研究DNA损伤反应抑制剂对于HBV感染和复制的作用成为可能。
In particular, dysfunction in DNA damage response and repair is a common feature in many human cancers, including colon cancers.
特别是，DNA损伤反应和修复的功能障碍是人类许多癌症的一个共同特征，其中包括结肠癌。
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