So our AIM: To investigate whether or not exogenous and endogenous histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats.
因此本文的目的:研究和阐明海马外源性和内源性组胺对地佐环平(MK-801)诱发大鼠的八臂迷宫记忆障碍的作用及探讨海马组胺受体在空间记忆中的作用。
参考来源 - 组胺改善地佐环平诱发的大鼠八臂迷宫记忆障碍和NRats of the intervention group were injected i. p. with dizocilpine (0.075 mg/kg) 30 minutes before morphine injections (identical to the morphine group). Rats of the control group were treated by saline according to control principle.
吗啡组大鼠每天两次腹腔注射吗啡,剂量逐日递增(5-50mg/kg/次),共10天;干预组大鼠于每次注射吗啡(同吗啡组大鼠)前30分钟腹腔注射地卓西平0.075mg/kg/次;对照组大鼠按同期对照原则注射生理盐水。
参考来源 - 吗啡依赖大鼠部分脑区基因表达、突触结构改变及其地卓西平的影响·2,447,543篇论文数据,部分数据来源于NoteExpress
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