pH of dissolution medium 释放介质的pH
It was found that quality control could achieve when using phosphate buffer of 40 %v/v polyethylene glycol 400 with 20%v/v isopropyl alcohol (pH=5) as dissolution medium and 50rmp stirring rate.
首先对释放介质和转速进行了选择,采用pH=5的40%v/v聚乙二醇400 20%v/v异丙醇磷酸缓冲液和转速为50转/分时能达到较好的质控目的。
参考来源 - 达那唑阴道膜剂的研制·2,447,543篇论文数据,部分数据来源于NoteExpress
Individual solutions may be directly prepared in the dissolution medium.
直接用溶出介质制备每一个溶液。
The dissolution step is the release of the drug inthe dissolution medium and sampling. The analytical finish is defined insection 3.
溶出步骤是指药物在溶出介质中的释放和取样,分析方法的定义详见第3章节分析方法。
Insome cases, where the drug substance can degrade in the dissolution medium(e. g. , dosage forms containing aspirin), it is useful to carry out themeasurements at the isosbestic point.
在某些情况下,药物在溶出介质中降解(例如,含有阿司匹林的制剂),适合在在等吸收点完成测定。
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