The early age of onset suggests a virulent disease pattern in the familial patients.

疾病早发性证明在遗传性的患者中该病是致命性的。

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Accurate staging is critical not only for managing individual patients, but also for ascertaining trends in disease pattern in a large population of patients with prostate cancer.

精确的分期不仅对于患者个体治疗，而且对于确定前列腺癌患者人群疾病模式的预后趋势来说都是非常关键的。

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Objective: To explore the feasibility of indirectly analyzing population disease pattern using inpatient categorization, and to raise strategies of disease prevention and control.

目的探讨通过住院患者疾病构成间接分析人群疾病谱的可行性，提出疾病预防与控制策略；

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Spending on a disease like cancer tends to follow a particular pattern.

NEWYORKER: Letting Go

However, Simon Cousens, an epidemiologist at the London School of Hygiene and Tropical Medicine, points out that such a pattern does not necessarily mean a disease outbreak is levelling off.

ECONOMIST: The BSE Inquiry

Other illnesses including heart disease, Alzheimer's disease and hormonal problems can also disturb the normal pattern of sleep.

BBC: High sleeping pill use 'worrying'