One of the big disincentives to placing weapons in space has been the technical difficulty and cost of such an enterprise.

一直以来，在太空部署武器的主要障碍之一就是技术难度以及该项事业的高昂成本。

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But, she notes, he might have sympathised with her over one big problem: the surprising difficulty of changing medical routine.

然而，她说过，Semmelweis在这个大问题看法应该和她一样：要改变医药程序得面临着惊人的困难。

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This plan need not be expensive, but it faces one big difficulty.

这项计划花费不大，但却面临一个很大的难题。

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Language is another big difficulty.

ECONOMIST: Europe's unwieldy patent regime

But his difficulty in giving that big speech on Europe in about a week's time is what if he's wrong on any one of those ifs?

BBC: David Cameron says there will be EU referendum if...

Regardless of the amount of difficulty involved, the big four emerging markets plus South Africa said earlier this week they were considering setting up a foreign-exchange reserve pool and a currency-swap arrangement in an effort to avoid any credit crisis stemming from the advanced economies.

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