This stage is significantly more difficult to reverse, requiring specialized counteragent.

这一阶段更是难以逆转，需要专门的对抗剂。

youdao

Once that has happened it will be very difficult to reverse.

一般这种情况发生，就会很难扭转。

youdao

This will make it exceedingly difficult to reverse the trend in the future.

这无疑使得在遥远的未来彻底改变这种状况难上加难。

youdao

The reason that it seems difficult to say though is because it seems like it would be just as plausible to say the reverse.

但真的要说出来似乎有困难,因为反过来说也貌似合理。

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While very difficult to reverse, the report said that specific local strategies should be employed to tackle spreading deserts.

CNN: Growing deserts 'a global problem'

United Grand Lodge will find it difficult to reverse the fall in membership.

ECONOMIST: Freemasonry

Given how low the expectations are for the team this year, it will be difficult to reverse that trend soon.

WSJ: New York Mets' Fred Wilpon: 'I Think We'll Be Fine'